Seropositivity of leptospirosis and related occupational and environmental factors among abattoir workers in Myanmar: a prerequisite for one health approach control practices Leptospirosis is a zoonosis of great importance of public health and considered one of the neglected tropical diseases affecting both human and animal populations. As this infection has occupational hazards for workers which keep direct or indirect contact with animals, mainly without adequately using protection measures, abattoir workers are on high risk of contracting leptospiral infection. Despite being prevalent as occupational zoonosis in resource limited setting like Myanmar, the information even for high-risk groups is scarce. This cross-sectional study aims to detect seropositivity of Leptospira antibodies and related occupational and environmental factors among abattoir workers. A total of blood samples from 180 abattoir workers from five registered abattoirs with license type-B or type-C situating in Yangon Region were collected and those workers were also interviewed about their occupational and environmental variables. All blood samples were tested for detection of Leptospira antibodies by using SD BIOLINE IgM/IgG Immunochromatographic Assay. Then, the seropositive samples were transported to another laboratory for further serological examination by using Indirect Immunofluorescence Assay (IFA) to minimize the false positives. Among 180 abattoir workers, 64% were from cattle, goat, sheep abattoirs and the remaining from pig abattoir. Most of them were in 18 to 34 years age group, males and urban residence. Around two-third had heavy exposure to blood, internal organs and viscera of animals and carcass due to their types of work such as slaughter workers, butchers and offal removers. Nearly half of workers did not wear any personal protective equipment (PPE) during work. Only 11.7% of workers had awareness on human leptospirosis. Twelve of 180 workers were seropositive of Leptospira antibodies, contributing to 6.7% (95% CI: 3.5%, 11.4%). Bivariate statistical tests revealed the significant association between the seropositivity and the occupational and environmental characteristics such as presence of heavy exposure to raw meat/ blood, duration of service in current work, habitude of smoking during work, habitude of eating during work and wearing PPE. Moreover, the marginally significant association was also observed between the factors such as the presence of mice or rat burrow at home or around neighbourhood, habitude of washing kitchen utensils before usage, and seropositivity. Since most of the study workers were lack of awareness on human leptospirosis, the awareness raising program such as health education about leptospirosis especially its modes of transmission and prevention methods should be promptly and intensively provided. The findings also highlighted the proportion of workers who had habitude of wearing PPE was substantially low and, in addition, wearing PPE and presence of heavy exposure of animal blood were found as the significant occupational factors for seropositivity. The study team, hence, recommends that the workers should wear appropriate PPE while working. This is the first report of seropositivity of leptospirosis in abattoir workers in Myanmar. The findings of this project may provide the baseline information required for planning and implementing effective prevention and control strategies for zoonotic diseases such as leptospirosis among abattoir workers. SEAOHUN 2022 Small Grants Project team leader: Dr. Aye Sandar Mon, Assoicate Professor, University of Public Health, Yangon Team members: Prof. Hla Hla Win, Rector, University of Public Health, Yangon, Prof. Mya Thandar, University of Public Health, Yangon, Dr. Myo Pa Pa Thet Hnin Htwe Aung, University of Medicine, Taunggyi, Dr. Aung Tin Kyaw, University of Public Health, Yangon - Personal protective equipment, distancing, and group size standards in this photo were consistent with local public health guidance and COVID-19 status in the specific country and time it was taken. This may not reflect best practices for all locations where COVID-19 is still spreading. -

Designing and evaluating intervention for prevention and control towards rabies among rural populations in Sabah, Malaysia Rabies is a significant but neglected disease predominantly transmitted through dog bites and responsible for an estimated 55,000 to more than 70,000 human deaths annually worldwide but occurring mostly in Asia and Africa. With continuous effort, Malaysia declared free from rabies in 2003. However, there were rabies outbreak occurred in three states in 2015 and in Sarawak in 2017. Hence, Sabah is considered high risk state because is neighbouring Sarawak. The Skuad PErangi Rabies (SPERA) Project was led by Dr Zulkhairul Naim bin Sidek Ahmad from Universiti Malaysia Sabah with the support of his team to maintain zero human rabies case among rural populations in Sipitang, Sabah. There were many activities conducted to achieve the goal of the project. Initially, the volunteers were trained on rabies prevention and control measures. Additionally, the volunteers were exposed to the concept of the program and their responsibilities in carrying out this program successfully for the community health benefits. They were informed regarding them being an active agent in informing and educating the community on the danger of danger and its prevention to curb the disease. They also act as a motivator for creating awareness among the community. Exhibition on rabies was conducted as well. During the exhibition, the materials related to rabies were displaced in the board. The final activity was door-to-door canvassing where the volunteers went to village’s home and distributed the rabies prevention and control tools consist of book, pamphlet, hand-fan, small badge and plastic bracelet. A total of 31 volunteers were trained in training of trainers (TOT) and nearly 250 participants attended this exhibition. During the door-to-door canvassing, the volunteers went to give health education to 157 adult villagers. Thanks to the funds and support provided by this SEAOHUN Small Grants Program, without a doubt, the villages were better equipped with knowledge and practice of rabies prevention and control and finally, the rabies case maintain zero in Sipitang district, Sabah, Malaysia. SEAOHUN 2022 Small Grants Project team leader: Dr Zulkhairul Naim bin Sidek Ahmad Team members: Dr John Michael Cabuguason, Dr. Jamsari bin Hashim - Personal protective equipment, distancing, and group size standards in this photo were consistent with local public health guidance and COVID-19 status in the specific country and time it was taken. This may not reflect best practices for all locations where COVID-19 is still spreading. -

Knowledge transfer and collaborative networking on building resilience against leptospirosis among visitors in recreational forests Terengganu, Malaysia. Almost a year ago we received the news that our allocation to the SEAOHUN Small Grant Program 2021 was accepted. We were jumping with joy! This is the beginning of Project Lepto- a project that we have initiated in collaboration with Faculty of Science and Marine Environment, Universiti Malaysia Terengganu (FSME UMT) with Institute of Tropical Biodiversity and Sustainable Development, Universiti Malaysia Terengganu (ITBSD UMT), Universiti Kebangsaan Malaysia (UKM) and Institute for Medical Research (IMR). Recreational forests in Malaysia are categorized as one of the important hotspots of leptospirosis outbreaks. Previous studies have indicated the risk of leptospirosis in recreational forests, and focused mainly on water-soil environmental reservoirs. However, information on the animal reservoirs remains under-highlighted. We laid out the project into a few objectives. First, we need to find out the diversity and composition of non-volant small mammals at Cemerong Recreational Forest, Terengganu by using 100 cage traps that were set up along the trail at the recreational area. Second, we are determined to know the prevalence of leptospirosis in the samples of the non-volant small mammals. The samples were determined by dissecting the individuals and obtaining the liver samples for testing purposes. Thirdly, we would like to imitate knowledge transfer activities for the public regarding the precautions and symptoms of leptospirosis. The first objective was determined by using identification of the small mammals diversity.The number of individuals caught from the sampling sessions was 51 individuals from 12 species. The most dominant species was house rat (Rattus rattus) with 14 individuals, followed by common treeshrew (Tupaia glis) and Whitehead’s maxomys (Maxomys whiteheadi) with 9 individuals respectively. Then from the liver sample, we tested the prevalence of leptospirosis in the individual. Our students managed to get training on the lab work at the IMR with Dr. Mohammad Ridhuan Mohd Ali (Research Officer). This collaboration allowed knowledge transfer among the two research institutes. We feel humbled by the training given by the expert such as Dr. Ridhuan, as well as the opportunities to use the lab and resource sharing for the laboratory work. We managed to get one sample containing Leptospira sp. With that finding, we can move forward for our next step with the Forestry Department to support the forest management work. How do we transfer our information to the public? We have two outputs that we managed to implement. First, we managed to install the signboard at Cemerong Recreational Forest, Terengganu, Malaysia. This signboard would allow the public to know more about symptoms of leptospirosis, what factors lead to the zoonotic disease and what can we do to prevent them from occurring. We also managed to include a QR code at the signboard leading to our website, of which we have included our team members, objectives of the project and brief database and photo of the small mammals and our team members on the field. This website is a great tool to uplift our visibility and expand our project in the future, especially with the extensive collaboration that we already have. We managed to implement a survey on the effectiveness of the communication regarding leptospirosis. We obtained 89 respondents, and significantly, social media is a great tool among the public to know more about this zoonotic disease, compared to other communication channels such as newspaper, radio, television and others. The infographic that we printed on the signboards also obtained great understanding as respondents have more awareness and understanding about this issue. This outcome is obtained from a pre-post test that we included in the survey. There are multiple pillars of the project such as field work, laboratory work and awareness through signboards and websites. We couldn't thank USAID and SEAOHUN for the seed funding provided to us to initiate this project, allowing knowledge transfer and training, and more visibility about the zoonotic disease. We hope that in future more collaboration and funding could be obtained, towards a better health and conservation effort of our world. SEAOHUN 2022 Small Grants Project team leader: Dr. Nur Juliani Shafie Team members: Dr. Nor Zalipah Mohamed, Dr. Aini Hasanah Abd Mutalib, Dr. Mohammad Ridhuan Mohd Ali, Dr. Farah Shafawati Mohd Taib, Dr. Norita binti Shamsudin, Tuan Haji Roslan bin Rani - Personal protective equipment, distancing, and group size standards in this photo were consistent with local public health guidance and COVID-19 status in the specific country and time it was taken. This may not reflect best practices for all locations where COVID-19 is still spreading. -

Rabies: Promoting the communities outreach program and welfare of pet’s animals to prevent future zoonotic diseases in Cambodia. It is estimated that 75% of human diseases comes from the zoonotic diseases that spread from animals including domestic and wild animals. One of them, Rabies has threatened hundreds of people around the world including Cambodia. To eliminate Rabies, Cambodian government has implemented strategies to eliminate by 2025. Reducing the human risks is one among of those strategies that aiming to 1) getting the communities educated and aware to protect themselves, their families, and their regions; 2) increase to health care, vaccinations and medicine; and 3) stray dog population control and massive vaccination. To share the effort, the Faculty of Veterinary Medicine of Royal University of Agriculture has partnered with Animal Rescue Cambodia (ARC), and Phnom Penh Animal Welfare Association (PPAWS) leading rabies awareness activity which is support by the SEAOHUN Small Grant 2021. The project aims 1) to train pet’s owner on rabies; 2) to preventing and reducing the pets expose to rabies through the vaccination, de-sexing, and other sanitation measures; and 3) to improve knowledge and skills of the pre-and in-service animal health professionals to prevent and control zoonotic disease such as Rabies. Surprisingly, the outcomes include: 97 pets’ owners have been increasing in knowledge about rabies after training. A total of 495 pets (130 dogs; 340 cats) received the rabies vaccination. 192 (20 dogs; 172 cats) of 347 pets have been successfully de-sexing; while 155 pets 145 dogs; 10 cats) supported by ARC for de-sexing. A total of 519 pets (153 dogs; 366 cats) received deworming. A total of 520 pets (181 dogs; 339 cats) received shampoo bathing. A total of 5 in-service and 5 pre-service indicated to improve their knowledge and skills on One Health approach to combat rabies. About 70 undergraduate veterinary students have been engaged in the program to gain the insight of the approach on rabies prevention activities. The project highlighted the successful outcomes for the approach to rabies prevention in Cambodia. Continuing the awareness of rabies and vaccinating/de-sexing pets across the veterinary clinics and extend to the communities contribute to the prevention of rabies in Cambodia. The team and students showing increase in knowledge and skills in one health and its approach for zoonosis prevention. We have followed up several team (from pre-service and in-service) to reflect what they learned and applied for their current work/study after the completion. We found all of them were very satisfied and showing their interest that project was beneficiary to their professions. “I have experienced good collaborating, planning, and managing while implementing the project. I acknowledged the project team, the SEAOHUN small grant 2021 that provided me a good opportunity to build my technical and soft skills as the professional veterinarian.” Miss. Uk Sovanpaktey, undergraduate vet students (selected student for working in project), faculty of veterinary medicine, Royal University of Agriculture and recently work at Animal Clinic in Phnom Penh. “I have gained much more knowledge about rabies and its prevention from the project. Furthermore, my team work, communication and consultation with pet owners, and ability of assisting in vaccination and de-sexing have been improved that lead me to be ready to perform well as a veterinarian professional.” Miss. Ouch Saoleap, a volunteer veterinary undergraduate of the faculty of veterinary medicine, Royal University of Agriculture. “My skills on the animal handling, vaccination, deworming, and de-sexing have been much more improved after joining this project. I learned that One Health Approach as used in this project is really good for preventing rabies in Cambodia. Surprisingly, partner (ARC) of the project give me an opportunity to conduct research thesis and training as the veterinarian professional.” Miss. Kim Socheatey, undergraduate vet students (selected student for working in project), faculty of veterinary medicine, Royal University of Agriculture. “As director of Animal Rescue Cambodia and MSc Shelter Medicine professional, I was very pleased to see the development of the project. Part of my academic and professional background focuses on High Quality High Volume Spay Neuter (HQHVSN). I see it as my responsibility to teach the highest and most modern standards of spay/neuter programs to the next generation of veterinary professionals, in order to provide the best possible standards for the animals we serve through spay/neuter campaigns. This project in particular showed that there is a large interest of young veterinary students wanting to learn high quality spay/neuter techniques and therefore, such projects are invaluable to set the pathway for future veterinary education in Cambodia. Moving forward from this project, I hope to see more veterinary students participating in internships and professional development programs in order to provide international veterinary standards to animals in Cambodia. Through my participation, I hope to have inspired students to become spay/neuter surgeons or veterinary technicians. Furthermore, I appreciate how the project has strengthened the positive collaboration between RUA and ARC by expanding beyond spay/neuter through lectures on animal welfare and internship opportunities for students.” Ms. Martina Mayr, director of Animal Rescue Cambodia and MSc in Shelter Medicine SEAOHUN 2022 Small Grants Project team leader: Miss. Saran Chhoey Team members: Prof. Dr. Kroesna Kang, Dr. Bunna CHEA, Dr. Phay Boureth, Mr. Dim Kanan, Miss. Kong Danin, Mr. Chhoem Changven, Miss. Kheav Eab - Personal protective equipment, distancing, and group size standards in this photo were consistent with local public health guidance and COVID-19 status in the specific country and time it was taken. This may not reflect best practices for all locations where COVID-19 is still spreading. -

Have you ever started to take an antibiotic on your own without a prescription? You bought 3 tablets of the medicine that made your uncle better a few weeks ago. Or maybe you know of someone who was sick with cough and fever and the doctor prescribed an antibiotic for a few days for cough and then forgot to take it when you started getting better? Or have you ever heard about prescription sharing? It is when members of one family may think that an antibiotic that worked for an infection of one member should work for everybody else. All of the above are examples of how we may unknowingly be using antimicrobials in a wrong way. And wrong use of antibiotics can encourage the development of antimicrobial resistance (AMR). Because of just how often these misuse of these precious medicines may be happening, AMR is considered to be one of the most serious global threats to public health today. AMR has been further intensified by the COVID-19 pandemic. AMR is a complex phenomenon where the bugs (like bacteria, virus, fungi, parasite) remain unfazed and continue to thrive despite the presence of antimicrobials. It sounds like a simple operational mishap yet the truth is AMR can be a very daunting problem threatening to become the next silent pandemic. The 2022 Lancet article which describes the global burden of AMR in 2019 before the pandemic, warns us that mortality associated with AMR is close to 5million across the globe. Our country data shows high resistance rates for common pathogens like the E coli, Klebsiella, Acinetobacter baumanni and MRSA. And many are unaware of AMR, its presence amidst us and it implications in our lives. There is an urgent need to increase awareness on AMR and collectively attempt to control, prevent and event stop AMR! For all these reasons, the Philippine team took the heed of the World Health Organization and used the opportunity of the SEAOHUN Grant to expand the reach of AMR advocacy. Every year, the world dedicates one week to celebrate the World Antimicrobial Awareness Week (WAAW). It is set every November 18-24. In 2021, we worked on reaching as many Filipinos, groups, schools, universities, companies, government and private agencies, and personalities in the country in a full blast nationwide all-inclusive participation in the WAAW. We built broader collaborations between schools and universities in the PhilOHUN; and across agencies and institutions involved in human, animal and environmental health for a sustainable advocacy One Health response. We challenged all to eliminate misuse and overuse of antimicrobials whether as a prescriber, dispenser, user, distributor, producer or consumer and be part of the solution! So over the seven days of the 2021 WAAW, we filled each day with events, activities and contests from which we shared what AMR was and how we could stop it. There was something for just about everyone! The week started with a show of force and commitment called the High-Level Media Forum. All the big leaders of the stakeholders were there and gave their word that they will support the AMR activities including from the WHO, FAO, OIE, UNEP, the PhilOHUN and 9 local agencies. The biggest hit group are the human health providers. There are more than 1000 health facilities in our country. And doctors, nurses, pharmacists have been become with efforts towards helping the prescribers prescribe better. This is a program called Antimicrobial Stewardship(AMS). During the 2021 WAAW we reinvigorated the AMS spirit by tickling their competitive streaks and calling for the Best AMR Infographic! We also had days dedicated to those working in the Animal Health Sector, our friends in industry and consumer groups. But the “GameChangers” without doubt were the tandem of the Youth and the Teachers! 2021 was the first year that we were able to involve the Youth! Through the student organization from the University of the Philippines called the “Medical Students for Social Responsibility”. The students creatively developed a Youth Conference on AMR entitled with a catchy title “YOUth against AMR” with an additional AMR Tiktok contest. On the other end of this undeniably great investment-high yield AMR advocates are the selfless 37,000 teachers in the public schools. In addition to their webinars, they also launched two contests for students on AMR and what could be done: Best AMR Vlog and Best AMR Essay! The innovativeness, creativity and wide participation in all the contests were outstanding! All 17 regions of the country had entries to all the Youth AMR contests. SEAOHUN 2022 Small Grants Project team leader: Regina Berba MD Team members: Prof. Melbourne Talactac, Dr. Mario Panaligan, Dr. Anna Melissa S. Guerrero

The SEAOHUN 2022 Student Summit (3-5 September 2022), one of the preceding events of SEAOHUN 2022 International Conference was hosted by Kasetsart University (KU), Kamphaeng Saen campus, in collaboration with Thailand One Health University Network (THOHUN), and with the support from Chevron through the Strengthening One Health Education in Southeast Asia project. With the theme of “Fostering One Health Leaders”, the summit brought together a total of 41 participants (34 students and 7 faculty advisors) from different One Health disciplines from Cambodia, Indonesia, Laos, Malaysia, Philippines, Taiwan, Thailand, and Vietnam. “Amazing experience with students from a variety of cultures and professions. Received theoretical information and also real-world experiences. We improved our One-Health core competencies through fun and inspiring activities. Definitely my pleasure and honor to participate in this event.” – Ms. Stephanie Chou, Student, National Yang Ming Chiao Tung University, Taiwan. On the afternoon of 3 September, ice-breaking activities (fun marshmallow tower building challenge), One Health introduction lectures and case-based problem-solving exercises were organized to warm up students for the following two days. The welcome dinner followed later that night, showcasing a Thai Boxing (Muay Thai) special performance from KU students and cultural exchange performances from the eight country teams, bringing the students closer with colorful traditional dances and songs. The summit was officially opened on 4 September with warm welcome remarks from representatives of host and partner organizations, accompanied by graceful Thai Cultural dance performances from KU students. On that day, the students were mixed into four groups, joining field visits to four local farms with respective group assignments of on-site learning. Each group visited one plant farm (tomato or orchid) and one aquaculture farm (shrimp or goldfish). The students gained practical knowledge by learning the production process (plant farms), identifying possible risks and food security issues (aquaculture farms) from a One Health perspective. “The Student Summit bridges the students throughout Asia to exchange their experiences and cultures while creates the next generation of One Health workforce. These students will protect our world from future pandemic threats” - Dr. Terdsak Yano, Faculty Advisor, Faculty of Veterinary Medicine, Chiang Mai University, Thailand. On the last day, the students displayed their excellent teamwork through group presentations of their field visit experiences by applying the theoretical and practical One Health knowledge gained during the last two days. The presentations were followed by discussions and valuable feedback from lecturers and facilitators of THOHUN before wrapping up with the certificate awarding ceremony. The in-person event was filled with fun activities of team building exercises, interactive learning at the campus as well as practical field visits to local farms. The students had the opportunity to learn and expand their knowledge in technical and soft skills, including systems thinking and communications. Despite the language and cultural boundaries, the students from different parts of the region bonded in no time while working together, learning each other’s cultures, building friendships and strengthening their professional networks. Hosting these events is an essential part of SEAOHUN’s student engagement work to foster students in our region to become future One Health Leaders. To view and download photo:https://photos.seaohun.org/SEAOHUN2022StudentSummit

Oppotunity to join! the 1st Research Conference on AMR/AMU in Food Animals in the Asia-Pacific Region (AMRU-Asia Pacific) to be held on 6-8 February 2023. AMRU-Asia Pacific 2023 is the first research conference that will be a platform for bringing together stakeholders from industry, academia, and government as well as other interested parties all over the world in the same virtual conference for research on antimicrobial resistance (#AMR) and antimicrobial use (AMU) in Asian and Pacific food animal production. AMRU-Asia Pacific 2023 is a fully virtual event with no cost registration for all attendees. Deadline until 31 January 2023. The conference emphasizes the research on AMR and AMU for food animal production conducted in Asia Pacific. For more information about the conference please visit: http://amru-asiapacific.com/

We are excited to announce USAID is recruiting a second cohort for the Digital Youth Council to begin in February 2023! The International #Youth Digital Leadership Council or “Digital Youth Council” is a 12-member council of young leaders between the ages of 16 and 24 dedicated to addressing digital harm, which includes sexual violence and exploitation, cyberbullying, misinformation, and radical extremism. We are looking for young change-makers who are working at the intersection of digital platforms and safety to leverage technology, digital development, professional networks, and digital skills to reduce digital harm for children and youth. Click here! https://www.youthlead.org/digital-youth-council to find more information and submit your completed applications using the online application form here: https://www.youthlead.org/funding/call-applications-2022-international-youth-digital-leadership-council Deadline until 11:59 p.m. EST on December 15, 2022.

Dr. Melbourne R. Talactac is the Vice President for Research and Extension of Cavite State University and currently serves as Chairperson of the Philippine One Health University Network. A distinguished veterinarian and researcher, he specializes in veterinary parasitology, immunology, and vaccine development, with a strong focus on zoonotic and vector-borne diseases. Dr. Talactac earned his Doctor of Veterinary Medicine degree in the Philippines and completed his doctoral training in Japan, where he conducted advanced research on host–parasite interactions and immunological responses. He has led numerous nationally and internationally funded research projects and has contributed significantly to strengthening One Health initiatives in the country through interdisciplinary collaboration among human, animal, and environmental health sectors. As a research leader, he has championed innovation, capacity building, and policy engagement to address emerging infectious diseases. His work continues to support scientific advancement, public health preparedness, and sustainable development in the Philippines and beyond.

Professor Mayfong Mayxay is the President of University of Health Sciences, Ministry of Health, Lao PDR; Chairman of the National Ethics Committee for Health Research; President of the Lao Infectious Disease Society; and Chairman of Lao One Health University Network (LAOHUN). He initiated many important academic entities in Laos, including a clinical research unit called “Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit” at Mahosot Hospital; the first Lao Ethical Committee and the first Lao Medical Journal. He co-founded the Lao One Health University Network, the Lao Infectious Disease Society and recently, the Unit for Health Evidence and Policy at the Lao University of Health Sciences. Professor Mayfong is an outstanding researcher recognized internationally and locally with more than 25-years experiences in both clinical and public health research. He won the Ambulatory Pediatric Associational Research Award in 2004 in USA and he received the Encouragement Award from the Hitachi Global Foundation Asia Innovation Award 2020. So far, he has published ~ 288 papers which are indexed in Pubmed.

Woutrina A. Smith, DVM, MPVM, PhD. School of Veterinary Medicine, UC Davis. Project Director, USAID One Health Workforce – Next Generation Project Dr. Smith is the Associate Dean for Global Programs and a Professor of Infectious Disease Epidemiology in the School of Veterinary Medicine at the University of California, Davis, USA. She leads the USAID One Health Workforce – Next Generation Project working with AFROHUN and SEAOHUN in 17 countries across Africa and Southeast Asia. Dr. Smith has worked on One Health research projects across Africa, Asia, and in the Americas, where multidisciplinary teams innovate together to solve complex health problems. She has received funding from diverse sources including the National Institutes of Health, the US Agency for International Development, the US Department of Defense, and the Bill & Melinda Gates Foundation to support her research and training programs.

Operationalizing the Environment Health Nexus in Asia and the Pacific: A Policy Guide on Opportunities for Enhancing Health, Biodiversity, Food System and Climate Action aims to support policymakers and stakeholders in the Asia-Pacific region to address environment-health risks and safeguard human health and well-being while protecting ecosystems. Specifically, it provides an overview of concrete opportunities to mainstream the environment-health nexus in public policies in Asia and the Pacific, including those pertinent to health, biodiversity loss, food systems, and climate change. It also lays out pathways to strengthen the enabling factors for operationalizing an environmentally comprehensive One Health approach. These enabling factors include multisectoral governance; integrated environment and health data and assessment; nature-based solutions; human rights-based approaches; stakeholder engagement and capacity-building; integrated environment-health funding streams; and regional cooperation. Download and read the report at SEAOHUN recommanded publications https://www.seaohun.org/publications or visit https://www.unescap.org/kp/2022/policy-guide-environment-health-nexus